How does doxorubicin cause cardiotoxicity?

How does doxorubicin cause cardiotoxicity?

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes.

What is a toxic effect of doxorubicin?

Doxorubicin extravasation during intravenous administration can result in severe tissue ulceration and necrosis, which worsens over time. Doxorubicin is also associated with significant cardiac toxicity, which limits the long-term use of the drug.

What are the symptoms of cardiac toxicity?

Symptoms of cardiac toxicity may include:

  • Chest pain.
  • Heart rhythm changes (arrhythmia).
  • Fatigue.
  • Shortness of breath.
  • Weight gain.
  • Swelling.

What is doxorubicin induced cardiomyopathy?

Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown.

How is cardiotoxicity diagnosed?

Standard current methods for detection of cardiotoxicity primarily involve serial measurement of the left ventricular ejection fraction (LVEF), a parameter that when reduced is a late manifestation in the cardiotoxic paradigm and when the possibility for reversibility declines.

How is cardiac toxicity diagnosed?

How is cardiac toxicity diagnosed? Cardiac toxicity is diagnosed with a number of examinations and tests: Heart sounds: Your doctor will listen for abnormal heart sounds with a stethoscope. An extra sound other than the normal “lub-dub” is called a murmur, and may be a sign that your heart is damaged.

Can cardiotoxicity be reversed?

With the exception of anthracyclines, cardiotoxicity from most targeting agents is reversible. Concomitant use of cardiotoxic drugs should be avoided, and early detection of asymptomatic cardiac dysfunction is important.