What are CD24 cells?
What are CD24 cells?
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.
Do neutrophils express CD24?
CD24 is highly expressed on neutrophils, but little is known about its modulation during infection and inflammation.
Is CD24 a receptor?
Other interactions with signaling proteins and receptors CD24 is also important in regulating T cell survival. T cells must regulate their proliferation to support a long-lived cell population, but can expand their numbers during immune activation (Boyman et al., 2009).
Is CD24 a stem cell marker?
CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast cancer. However, their expression is not always consistent even in the same subtype of breast cancer.
Do macrophages express CD24?
CD24 is expressed on hematopoietic cells, including B cells,3, 8, 29, 30, 31, 32 T cells,33, 34, 35, 36, 37 neutrophils,37, 38 eosinophils,39 dendritic cells36, 40, 41 and macrophages,42 as well as on non-hematopoietic cells, including neural cells,10, 43, 44, 45, 46 ganglion cells,47, 48 epithelia cells,49, 50, 51, 52 …
Do neutrophils express CD45?
Blood and BALF neutrophils can be identified by a CD16bright and CD45dim phenotype. The neutrophil population in peripheral blood can be distinguished by flow cytometry based on their forward- and side-scatter characteristics.
Do NK cells express CD24?
Two CAR-NK cells currently under development include CARs against CD24 and mesothelin. CD24, a cancer stem cell marker, is rarely expressed in non-hematologic healthy tissue, and associated with poor clinical outcome in OC patients (166, 167).