What causes thrombocytosis in cancer?

What causes thrombocytosis in cancer?

Some cases of cancer associated thrombocytosis are also due to either the inflammation evoked by the cancer, or by direct tumor production of IL-6. Far less understood is the cause of iron deficiency induced thrombocytosis.

What is the most common cause of thrombocytosis?

Essential thrombocythemia (ET) was the most common cause of primary thrombocytosis. Among secondary, non-infectious etiologies, tissue damage was the most common, followed by malignancy and iron-deficiency anemia. The most common infectious causes of thrombocytosis were soft-tissue, pulmonary and GI infections.

What are the causes of thrombocytosis?


  • Acute bleeding and blood loss.
  • Cancer.
  • Infections.
  • Iron deficiency.
  • Removal of your spleen.
  • Hemolytic anemia — a type of anemia in which your body destroys red blood cells faster than it produces them, often due to certain blood diseases or autoimmune disorders.

Is thrombocytosis and thrombocythemia the same?

Thrombocythemia (THROM-bo-si-THE-me-ah) and thrombocytosis (THROM-bo-si-TO-sis) are conditions in which your blood has a higher than normal number of platelets (PLATE-lets). Platelets are blood cell fragments. They’re made in your bone marrow along with other kinds of blood cells.

What kind of cancer causes thrombocytosis?

Thrombocytosis is an adverse prognostic factor in many types of cancer. These include breast cancer, ovarian and other gynecologic cancers, renal cell carcinoma and lung cancers.

What cancers are associated with thrombocytosis?

Lung and colorectal cancers were the most commonly diagnosed cancers in the thrombocytosis cohort. Lung and colorectal cancer were much more commonly diagnosed in patients with thrombocytosis than in the general population, and breast and prostate cancer were much less commonly diagnosed (Figure 4).

Is thrombocythemia hereditary?

Most cases of essential thrombocythemia are not inherited. Instead, the condition arises from gene mutations that occur in early blood-forming cells after conception.

What happens when you have thrombocytosis?

Thrombocytosis refers to having too many platelets in your blood. Platelets are blood cells in plasma that stop bleeding by sticking together to form a clot. Too many platelets can lead to certain conditions, including stroke, heart attack or a clot in the blood vessels.

What causes secondary thrombocytosis?

The pathophysiology of secondary thrombocytosis may differ, depending on the cause of thrombocytosis. Thrombocytosis is driven by overproduction of thrombopoietin, interleukin-6, other cytokines, or catecholamines in inflammatory, infectious, or neoplastic conditions or in situations of stress.

Is thrombocytosis always cancer?

Researchers have found evidence to suggest that thrombocytosis is a strong predictor of cancer, particularly lung and colorectal cancer. The team therefore believes patients with thrombocytosis should be evaluated for an underlying malignancy, as such investigation could speed up cancer diagnosis and save lives.

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