What does 11b HSD2 do?
What does 11b HSD2 do?
The placenta produces a molecule called 11 β -hydroxysteroid dehydrogenase type 2 (11 β -HSD2) which protects the fetus by metabolizing maternal cortisol that reaches the placental circulation. This protection is important as endogenous and synthetic glucocorticoids can reduce fetal growth.
What is the HSD enzyme?
Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs).
What is the fat burning hormone called?
Leptin is a hormone released by fat cells. It helps regulate how many calories you burn and how much you eat, which in turn regulates how much fat tissue your body stores.
Where is 11 beta hydroxysteroid dehydrogenase found?
HSD-11β Type 1 acts as a reductase producing active cortisol and the amplification of glucocorticoids. This enzyme is most abundant in the liver but can be found in most tissues in the body.
What is cortisol function?
Cortisol is an essential hormone that affects almost every organ and tissue in your body. It plays many important roles, including: Regulating your body’s stress response. Helping control your body’s use of fats, proteins and carbohydrates, or your metabolism.
What is the function of HSD 11 beta?
HSD-11βs are enzymes involved in steroid hormone physiology. HSD-11β Type 1 is found in metabolic tissues targeted by glucocorticoids and converts cortisone to active cortisol. HSD-11β Type 1 acts as a reductase producing active cortisol and the amplification of glucocorticoids.
What is the function of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD)?
The two 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) isozymes catalyze the interconversion of cortisol and cortisone. Type 1 11 beta-HSD (11 beta-HSD1) has bidirectional activity, while type 2 11 beta-HSD (11 beta-HSD2) mainly converts cortisol into cortisone.
What is the function of 11β-ohsd2?
11-β-hydroxysteroid dehydrogenase type-2 (11β-OHSD2) is the enzyme that converts cortisol into its receptor-inactive congener cortisone. Since cortisol binds with equal affinity as aldosterone to mineralocorticoid receptors (MRs), 11β-OHSD2 serves as a critical metabolic shuttle to protect MRs from exposure to cortisol.
What does HSD11B2 oxidize?
In these tissues, HSD11B2 oxidizes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.