What is a clear cell renal cell carcinoma?

What is a clear cell renal cell carcinoma?

Clear cell renal cell carcinoma, or ccRCC, is a type of kidney cancer. The kidneys are located on either side of the spine towards the lower back. The kidneys work by cleaning out waste products in the blood. Clear cell renal cell carcinoma is also called conventional renal cell carcinoma.

What is clear cell histology?

In histology, a clear cell is a cell that shows a clear cytoplasm when stained with hematoxylin and eosin (H&E).

What is RCC pathology?

Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. RCC is the most common type of kidney cancer in adults, responsible for approximately 90–95% of cases.

Why are cells clear in clear cell carcinoma?

They are so named because the cancer cells typically have abundant clear cytoplasm due to the presence of intracytoplasmic glycogen, which is lost during processing (Fig. 4).

Is clear cell renal carcinoma malignant?

Clear cell renal cell carcinoma (CCRCC) is a renal cortical tumor typically characterized by malignant epithelial cells with clear cytoplasm and a compact-alveolar (nested) or acinar growth pattern interspersed with intricate, arborizing vasculature.

What is clear cell renal cell carcinoma grade 3?

A person with clear cell renal cell carcinoma (ccRCC) has kidney cancer in the tubules that filter waste from blood. The cancer cells look like clear bubbles under a microscope. ccRCC is the most common kidney cancer. Surgery (nephrectomy) to remove the tumor or kidney can diagnose and treat this cancer.

What is the function of clear cells?

You can clear cells to remove the cell contents (formulas and data), formats (including number formats, conditional formats, and borders), and any attached comments. The cleared cells remain as blank or unformatted cells on the worksheet.

Who histologic classification of RCC?

Currently, according to the 2004 WHO classification, several histological RCC subtypes are recognized (Table 1). The most frequent histological subtypes include clear cell renal cell carcinomas (ccRCC), papillary renal cell carcinomas (pRCC), and chromophobe renal cell carcinomas (crRCC) (Figure 1).

How do you diagnose renal cell carcinoma?

How is renal cell carcinoma diagnosed?

  1. complete blood count — a blood test conducted by drawing blood from your arm and sending it to a lab for evaluation.
  2. CT scan — an imaging test that allows your doctor to take a closer look at your kidneys to detect any abnormal growth.

What are clear cell features?

Necrosis, hemorrhage, cystic degeneration, and calcification are common; these features give the clear cell RCC its characteristic heterogeneous appearance on imaging studies. Histologically, clear cell RCC is composed of cells with abundant cytoplasm that is clear, granular, or a mixture of both.

How serious is clear cell carcinoma?

Patients with clear cell renal cell carcinoma (CCRCC) tend to have a worse prognosis than patients with other histologic subtypes of RCC, with 5-year disease-specific survival rates of 50-69%, compared with 67-87% for papillary RCC and 78-87% for chRCC.

Is clear cell carcinoma benign or malignant?

A summary of the histological subtypes for benign and malignant tumors are demonstrated in table 1. The most common histology was clear cell RCC, which occurred in 63% of all patients, followed by papillary RCC, chromophobe RCC, and oncocytoma….Table 1.

Benign Tumors No. Tumors (%)
RCC Unclassified 98 (4)