What is a Gastroenteropancreatic neuroendocrine tumor?

What is a Gastroenteropancreatic neuroendocrine tumor?

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs), also known as carcinoids and islet cell tumors, are tumors derived from neuroendocrine cells that can occur anywhere along the gastrointestinal tract and comprise a heterogeneous family of neoplasms with a wide and complex spectrum of clinical behavior.

What does Gastroenteropancreatic mean?

A rare type of tumor that can form in the pancreas or in other parts of the gastrointestinal tract, including the stomach, small intestine, colon, rectum, and appendix. Gastroenteropancreatic neuroendocrine tumors usually form in cells that secrete hormones.

What does GEP NET stand for?

A gastroenteropancreatic neuroendocrine tumor (GEP-NET) is a rare type of tumor that can grow in the pancreas or other areas of the gut, such as the stomach, small intestine, rectum, colon, or appendix.

Who classification of GEP-NETs?

WHO 2010 definitions. The revolution of the 2010 WHO classification is the assumption that all GEP-NETs should be considered as potential malignant tumours and the stratification in malignancy-related risk groups is based on tumour grading and TNM staging [1].

Is neuroendocrine tumor cancerous?

Overview. Neuroendocrine tumors are cancers that begin in specialized cells called neuroendocrine cells. Neuroendocrine cells have traits similar to those of nerve cells and hormone-producing cells. Neuroendocrine tumors are rare and can occur anywhere in the body.

What are neuroendocrine cells?

Neuroendocrine cells are cells that receive neuronal input (neurotransmitters released by nerve cells or neurosecretory cells) and, as a consequence of this input, release message molecules (hormones) into the blood.

Who manufactures Lutathera?

Novartis
Basel, October 19, 2018 – Novartis today announced presentation of a new analysis of Lutathera ® (lutetium Lu 177 dotatate*) NETTER-1 data at the 2018 European Society for Medical Oncology (ESMO) congress examining the impact of Lutathera treatment on patients with low, medium or high liver tumor burden.

What is a Grade 1 Net?

The WHO grades for NETs include: Grade 1 (low-grade tumor): These cells divide at a low rate and therefore grow slowly. Grade 2 (intermediate-grade tumor): These cells divide at an intermediate rate. Grade 3 (high-grade tumor): These cells divide at a fast rate and therefore grow quickly.

What are examples of neuroendocrine tumors?

Some examples of neuroendocrine tumors are carcinoid tumors, islet cell tumors, medullary thyroid cancer, pheochromocytomas, neuroendocrine carcinoma of the skin (Merkel cell cancer), small cell lung cancer, and large cell neuroendocrine carcinoma (a rare type of lung cancer).

What is the survival rate of neuroendocrine tumors?

The 5-year survival rate for people with a GI tract NET that has not spread to other parts of the body from where it started is 97%. If the tumor has spread to nearby tissue or the regional lymph nodes, the 5-year survival rate is 95%. If the tumor has spread to distant areas of the body, the survival rate is 67%.

What are the new and emerging treatment options for gastroenteropancreatic neuroendocrine tumors?

New and Emerging Treatment Options for Gastroenteropancreatic Neuroendocrine Tumors. Clinical Advances in Hematology & Oncology. May 2015. Targeted Therapies Sunitinib and Everolimus Improve Survival for Patients With Rare Type of Pancreatic Cancer. National Cancer Institute. November 7, 2016.

What is the prevalence of gastroenteropancreatic neuroendocrine tumor (GEP-NET)?

Prevalence of Gastroenteropancreatic Neuroendocrine Tumors. Researchers estimate that only 8 people in 100,000 will develop a GEP-NET, according to an article published in March 2017 in the journal Archives of Medical Science, although assessments vary depending on the source. ( 6) While GEP-NETs are considered rare,…

What is the islet organ of the pancreas?

The islet organ (endocrine pancreas) consists of diffusely scattered, mostly small islets and isolated patches of cells among and within the exocrine acini.

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