What is acetylation polymorphism?

What is acetylation polymorphism?

The acetylator polymorphism is a genetically determined dif. ference in the A/-acetylation of a variety of aromatic amines and. hydrazines. In both humans and rabbits, individuals are either. rapid or slow acetylators, and slow acetylation is the recessive.

What drug metabolism does n acetylation?

Drugs known to be metabolized by this pathway include procainamide, hydralazine, isoniazid, sulfapyridine, sulfadimidine, dapsone, an amine metabolite of nitrazepam, and some carcinogenic aromatic amines.

What is N acetylation?

N-terminal acetylation (Nt-acetylation) is a widespread protein modification among eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino group, the charge, hydrophobicity, and size of the N-terminus is altered in an irreversible manner.

What is fast Acetylators and slow acetylators?

The slow acetylator phenotype often experiences toxicity from drugs such as isoniazid, sulfonamides, procainamide, and hydralazine, whereas the fast acetylator phenotype may not respond to isoniazid and hydralazine in the management of tuberculosis and hypertension, respectively.

What do n Acetyltransferases do?

N-acetyltransferase (NAT) is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to arylamines, arylhydroxylamines and arylhydrazines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA.

What are Acetylators?

[ah-set″ĭ-la´ter] an organism capable of metabolic acetylation. Individuals that differ in their inherited ability to metabolize certain drugs, e.g., isoniazid, are termed fast or slow acetylators.

What are Arylamine drugs?

Arylamine N-acetyltransferases (NATs) are polymorphic drug-metabolizing enzymes, acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides. The slow NAT phenotype increases susceptibility to hydralazine and isoniazid toxicity and to occupational bladder cancer.

What are slow acetylators and fast Acetylators?