What is deltaFosB?
What is deltaFosB?
DeltaFosB – more commonly written as ΔFosB – is a truncated splice variant of the FOSB gene. ΔFosB has been implicated as a critical factor in the development of virtually all forms of behavioral and drug addictions.
How long does deltaFosB last?
deltaFosB, like CREB, is induced in the NAc and certain other regions by chronic exposure to drugs of abuse, however, unlike CREB, deltaFosB is long-lived in that it persists in brain for as long as 6-8 weeks after cessation of drug administration.
How long does FosB last?
Although the ΔFosB signal is relatively long-lived, it is not permanent. ΔFosB degrades gradually and can no longer be detected in brain after 1–2 months of drug withdrawal, even though certain behavioral abnormalities persist for much longer periods of time.
What are nucleus accumbens?
Abstract. Introduction: The nucleus accumbens is considered as the neural interface between motivation and action, playing a key role on feeding, sexual, reward, stress-related, drug self-administration behaviors, etc.
What does Fos do in the brain?
c-Fos is currently used as a marker of neuronal activity and has been associated with a number of neural and behavioral responses to acute stimuli expression.
What causes c-Fos expression?
A variety of stimuli, including serum, growth factors, tumor promoters, cytokines, and UV radiation induce their expression. The c-fos mRNA and protein is generally among the first to be expressed and hence referred to as an immediate early gene. It is rapidly and transiently induced, within 15 minutes of stimulation.
What is fos expression?
Expression of c-fos is an indirect marker of neuronal activity because c-fos is often expressed when neurons fire action potentials. Upregulation of c-fos mRNA in a neuron indicates recent activity. The c-fos promoter has also been utilised for drug abuse research.
What is FOS in biology?
FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene.
What is c-Fos in the brain?
c-Fos is an immediate early response gene involved in cell proliferation and differentiation after extracellular stimuli, whereas its deregulation has been associated to oncogenic progression.