What is the action of gentamicin?

What is the action of gentamicin?

Gentamicin is bactericidal and is a broad spectrum antibiotic (except against streptococci and anaerobic bacteria). Its mechanism of action involves inhibition of bacterial protein synthesis by binding to 30S ribosomes.

What drugs does gentamicin interact with?

Some affected drugs include: amikacin, tobramycin, amphotericin B, cidofovir, cisplatin, polymyxin B, cephalosporins such as cephaloridine, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, among others.

What cranial nerve is affected by gentamicin?

In patients receiving Gentamicin(e) therapy, the function of the eighth cranial nerve (auditory and vestibular branches) should be carefully monitored as these changes may not be manifested until after completion of therapy, and are usually irreversible.

Which drug should not be used with gentamicin?

Before taking this medicine You should not use gentamicin if you are allergic to gentamicin or similar antibiotics such as amikacin, kanamycin, neomycin, paromomycin, streptomycin, or tobramycin.

What is the indication of gentamicin?

Indications : gentamicin is indicated in bacteraemia, urinary tract infections, chest infections, severe neonatal infections and other serious systemic infections due to susceptible organisms, in adults and children including neonates.

Why gentamicin is used as positive control?

Gentamicin (10 microg) was used as a positive control. Results: The methanol extracts showed weak antibacterial activity against the study organisms compared to Gentamicin. All extracts exhibited a significant bactericidal activity against S. aureus while L.

What are the properties of gentamicin?

3.1Computed Properties

Property Name Property Value
Molecular Weight 477.6
XLogP3-AA -4.1
Hydrogen Bond Donor Count 8
Hydrogen Bond Acceptor Count 12

Why does gentamicin cause ototoxicity?

In this situation gentamicin can accumulate in the tissues, leading to ototoxicity despite normal serum concentrations. Initial studies suggested that uptake of gentamicin by the inner ear rapidly leads to saturation but the drug is only slowly released.

Is gentamicin commonly used?

Gentamicin is the most commonly used aminoglycoside, but amikacin may be particularly effective against resistant organisms. Aminoglycosides are used in the treatment of severe infections of the abdomen and urinary tract, as well as bacteremia and endocarditis.

When is gentamicin contraindicated?

Hypersensitivity to gentamicin and myasthenia gravis is a contraindication to its use. Patients should be well hydrated during therapy, and renal function should be monitored. Dose adjustment is required in impaired renal function.

What is gentamicin side effects?

Common side effects of gentamicin include:

  • Neurotoxicity (spinning sensation [vertigo], loss of control of bodily movements)
  • Gait instability.
  • Ototoxicity (auditory, vestibular)
  • Kidney damage (decreased CrCl)
  • Kidney damage if trough greater than 2 mg/L.
  • Swelling (edema)
  • Rash.
  • Itching.

What is the mechanism of action of gentamicin?

Gentamicin is a broad spectrum aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth.

What are the side effects of gabapentin enacarbil with gentamicin?

Furosemide may increase the ototoxic activities of Gentamicin. Gabapentin enacarbil may decrease the excretion rate of Gentamicin which could result in a higher serum level. Gadobenic acid may decrease the excretion rate of Gentamicin which could result in a higher serum level.

Can gabapentin or framycetin increase the excretion rate of gentamicin?

Framycetin may decrease the excretion rate of Gentamicin which could result in a higher serum level. Furosemide may increase the ototoxic activities of Gentamicin. Gabapentin enacarbil may decrease the excretion rate of Gentamicin which could result in a higher serum level.

What is gabapentin used to treat?

Gabapentin is an anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.