What is the difference between peripheral and central sensitization?

What is the difference between peripheral and central sensitization?

Peripheral sensitization is due to posttranslational and transcription changes in the terminal ends of high-threshold nociceptors resulting in primary hyperalgesia . Central sensitization in contrast typically manifests in tactile allodynia and secondary hyperalgesia (in tissue not affected by any harmful condition).

What is central sensitization inventory?

The Central Sensitization Inventory (CSI) is a new self-report screening instrument to help identify patients with Central Sensitivity Syndromes, including fibromyalgia.

What does peripheral Sensitisation mean?

Abstract. Peripheral sensitization indicates increased responsiveness and reduced threshold of nociceptive neurons in the periphery to the stimulation, which usually occurs after peripheral tissue injury and inflammation.

What are the two types of sensitization?

Summary. Central sensitization with allodynia makes normally pain-free sensations hurt, while central sensitization with hyperalgesia intensifies pain from normally painful events.

Where does peripheral Sensitisation occur?

Peripheral sensitization This occurs in response to chemical mediators released by nociceptors and non-neuronal cells (e.g. mast cells, basophils, platelets, macrophages, neutrophils, endothelial cells, keratinocytes and fibroblasts) at the site of tissue injury or inflammation.

What are three conditions of central sensitization?

Factors leading to central sensitization following onset of pain. Antecedent factors can also play a role in the development of central sensitization. The onset of pain is often associated with subsequent development of conditions such as depression, fear-avoidance, anxiety and other stressors.

How do you score central Sensitisation inventory?

The CSI Part A score was divided into five categories with increasing severity: subclinical (0–29), mild (30–39), moderate (40–49), severe (50–59), and extreme (60–100) [18]. We determined the number of patients with a score of 40 points or higher based on previous studies as shown in Fig.

How do you score the CSI?

Total scores on the CSI range from 0-100, with the following severity ranges recommended:

  1. Subclinical = 0 to 29;
  2. Mild = 30 to 39;
  3. Moderate = 40 to 49;
  4. Severe = 50 to 59;
  5. Extreme = 60 to 100.

Is peripheral Sensitisation normal?

Sensitization is a heightened sensitivity to stimuli that may occur normally in the central or peripheral nervous system, but this condition is also present in many chronic pain conditions. In pathological conditions, sensitization may produce pain stimuli even if no harmful events are occurring.

What is an example of central sensitization?

Patients who find themselves suffering from forms of central sensitization experience pain from stimuli that should not induce pain. Things as gentle as brushing the back of a hand with a cotton ball can cause extreme, intense pain.

What causes central Sensitisation?

Central sensitization occurs through a process called wind-up, leaving the involved part of the nervous system in a state of high reactivity. This high reactivity lowers the threshold for what causes pain and leads to maintaining pain even after the initial injury has healed.

What is the best description of central sensitization?

Instead, central sensitization represents an abnormal state of responsiveness or increased gain of the nociceptive system. The pain is effectively generated as a consequence of changes within the CNS that then alter how it responds to sensory inputs, rather than reflecting the presence of peripheral noxious stimuli.

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