What is the function of Tsix?
What is the function of Tsix?
Tsix is transcribed antisense to Xist and regulates Xist expression. Several research groups have investigated the mechanism of Xist expression regulation. Since Tsix is also a noncoding RNA gene, it was suggested that the transcript itself is responsible for the repression of Xist expression.
Is TSIX a lncrna?
The two most prominent lncRNAs are Xist and Tsix.
What is Xist gene?
Xist (X-inactive specific transcript) is a non-coding RNA on the X chromosome of the placental mammals that acts as a major effector of the X-inactivation process. It is a component of the Xic – X-chromosome inactivation centre – along with two other RNA genes (Jpx and Ftx) and two protein genes (Tsx and Cnbp2).
What is the relationship between Xist and Tsix?
Xist and Tsix, two overlapping antisense-transcribed noncoding genes, are central elements of the X inactivation center (Xic) regulating XCI. Xist upregulation results in the coating of the entire X chromosome by Xist RNA in cis, whereas Tsix transcription acts as a negative regulator of Xist.
Is bar a body?
A Barr body (named after discoverer Murray Barr) or X-chromatin is an inactive X chromosome in a cell with more than one X chromosome, rendered inactive in a process called lyonization, in species with XY sex-determination (including humans).
How many Barr bodies are in XXY male?
one Barr body
These masses are called Barr bodies after the cytologist who discovered them. XX females have one Barr body per cell, XXX females have 2 Barr bodies per cell, and XXY Klinefelter males have one Barr body per cell (Barr bodies are not observed in XY males).
How do noncoding RNAs regulate gene expression?
Gene expression is regulated by lncRNAs at multiple levels. By interacting with DNA, RNA and proteins, lncRNAs can modulate chromatin structure and function and the transcription of neighbouring and distant genes, and affect RNA splicing, stability and translation.