What is the prevalence of Duchenne muscular dystrophy?
What is the prevalence of Duchenne muscular dystrophy?
Duchenne muscular dystrophy (DMD) is a rare muscle disorder but it is one of the most frequent genetic conditions affecting approximately 1 in 3,500 male births worldwide. It is usually recognized between three and six years of age.
How common is muscular dystrophy in Canada?
Muscular Dystrophy is the umbrella name used to cover the 160-plus known neuromuscular disorders today. While the disorders we represent are individually rare, they are collectively common, impacting more than 50,000 Canadians from coast to coast.
What race is Duchenne muscular dystrophy most common?
It appears that DMD is significantly more common in white males than in males of other races.
Is Duchenne muscular dystrophy more common in males or females?
Duchenne muscular dystrophy usually affects males. However, females are also affected in rare instances.
What percent of the population has DMD?
The pooled global DMD prevalence was 7.1 cases (95% CI: 5.0–10.1) per 100,000 males and 2.8 cases (95% CI: 1.6–4.6) per 100,000 in the general population, while the pooled global DMD birth prevalence was 19.8 (95% CI:16.6–23.6) per 100,000 live male births.
What percentage of the population has muscular dystrophy?
According to the literature review, the most common types of muscular dystrophy are myotonic dystrophy, with a prevalence ranging between 0.5 and 18.1 per 100,000, DMD with a prevalence of 1.7 and 4.2 per 100,000, and FSHD, with a prevalence between 3.2 and 4.6 per 100,000.
How many cases of muscular dystrophy per year?
The study estimated the diagnosed incidence of DMD in the US at 17.24 per 100,000 live male births in 2019. This corresponds to about 362 cases in that year. The diagnosed prevalence of the disease was 6.09 per 100,000 males across all age groups. This corresponds to about 10,015 cases.
How long can u live with Duchenne muscular dystrophy?
Median life expectancy was 22.0 years (95% confidence interval [CI] 21.2, 22.4). Analyses stratified by 3 time periods in which patients were born showed markedly increased life expectancy in more recent patient populations; patients born after 1990 have a median life expectancy of 28.1 years (95% CI 25.1, 30.3).
What population is most affected by DMD?
Duchenne muscular dystrophy mostly affects boys and occurs in one in 3,500 to 5,000 newborns. There is no higher risk for any ethnic group. Children affected by DMD may have some degree of cognitive problems, yet some have average or even higher-than-average intelligence.
Is DMD hereditary?
DMD is inherited in an X-linked pattern because the gene that can carry a DMD-causing mutation is on the X chromosome. Every boy inherits an X chromosome from his mother and a Y chromosome from his father, which is what makes him male. Girls get two X chromosomes, one from each parent.