What is the reaction involved during synthesis of aspirin from salicylic acid?
What is the reaction involved during synthesis of aspirin from salicylic acid?
To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In this experiment, sulfuric acid will be used as the catalyst. The excess acetic anhydride will be quenched (reacted) with the addition of water.
What is the reaction equation for the synthesis of acetylsalicylic acid?
*The chemical equation corresponding to the synthesis reaction is: C7H6O3 + (CH3CO)2O → C9H804 + CH3COOH.
Is the synthesis of aspirin exothermic or endothermic?
exothermic reaction
In a reaction vessel salicylic acid, acetic anhydride and sulfuric acid are mixed. The exothermic reaction will cause the temperature to increase to 70-80°C.
What is the role of sulfuric acid in aspirin synthesis?
The purpose of adding sulphuric acid (catalyst) is to aid and augent the process of detaching the acetate ion (CH3COO–) from acetic anhydride which ultimately gets associated with H+ ion from phenolic hydroxy group in salicylic acid to be eliminated as a mole of acetic acid. Aim: To prepare aspirin from salicylic acid.
What is the pharmacodynamics of aspirin?
Pharmacology/Pharmacokinetics Aspirin is rapidly absorbed in the upper gastrointestinal (GI) tract and results in a measurable inhibition of platelet function within 60 minutes. This antiplatelet effect is associated with prolongation of the bleeding time and inhibition of TXA2-dependent platelet aggregation.
Why does aspirin undergo hydrolysis?
Aspirin is a pain reliever and fever reducer, but if it’s allowed to react with water then it can undergo hydrolysis, forming salicylic acid and acetic acid, which is no longer effective. This reaction can occur under acidic or basic conditions.
How do you synthesis salicylic acid from phenol?
Phenol is heated with carbon tetrachloride in presence of aq. NaOH at 34)K and the product so obtained on hydrolysis with dil. HCl gives salicylic acid.
When was salicylic acid synthesized?
In 1829, the french pharmacist Pierre Joseph Leroux isolated salicin. Raffaelle Piria was the first to synthesize salicylic acid from salicin (salicoside).