What is the result of PDGF?
What is the result of PDGF?
Platelet-Derived Growth Factor (PDGF) PDGF stimulates the growth of its target cells, but also affects chemotaxis, i.e., directed cell movement, and cell shape through reorganization of the actin filament system. PDGF also affects the differentiation of specific cell types and promotes cell survival.
What is PDGF and its function?
Platelet-derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes-macrophages and fibroblasts in vitro, cell types considered essential for tissue repair.
What is PDGF?
A family of molecules released from platelets (tiny pieces of cells that are found in the blood and that help the blood clot). Forms of PDGF help to heal wounds and to repair damage to blood vessel walls. They also help blood vessels grow. Also called platelet-derived growth factor.
What secretes PDGF?
PDGF is secreted by platelets, macrophages, osteoblasts and fibroblasts. In addition to its mitogenic and chemoattractive properties, PDGF will increase osteoprotegerin expression in vascular smooth muscle cells (an inhibitor of osteoclasts) and functions during embryonic development [56].
How does PDGF induce cells to re enter the cell cycle?
How does PDGF induce cells to re-enter the cell cycle? A. Binding of PDGF to the PDGF receptor activates a signal transduction pathway that stimulates production of the G1 cyclin B. Binding of PDGF to the PDGF receptor activates a signal transduction pathway that stimulates production of a cyclin-dependent kinase C.
How is PDGF made?
Although PDGF is synthesized, stored, and released by platelets upon their activation, it can also be produced by other cells; this includes smooth muscle cells, activated macrophages, and endothelial cells.
What protein is activated by PDGF?
PDGF-BB activates protein kinase C that leads to the activation of the mitogen-activated protein kinase (MAPK) pathway. In some cells, PDGF signaling can lead to the phosphorylation of ERK 1/2 (extracellular signal-regulated kinase 1/2) that can further phosphorylate cytoplasmic phospholipase A2 (cPLA2).