What is Thrombin-JMI?

What is Thrombin-JMI?

THROMBIN-JMI is a topical thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical. ( 1)

What is THROMBIN used for?

Thrombin is a topical hemostatic agent used to control and minimize blood loss during surgical procedures, is utilized in conjunction or as an alternative to standard surgical techniques.

How do you administer THROMBIN?

Affix spray tip by pushing down and turning clockwise until the spray tip locks in place. To spray, depress the syringe plunger in a normal fashion to dispense the THROMBIN-JMI thrombin solution through the tip in a fine spray. Discard unused contents and syringe.

How is bovine THROMBIN made?

THROMBIN-JMI, THROMBIN, Topical (Bovine), is a protein substance produced through a conversion reaction in which prothrombin of bovine origin is activated by tissue thromboplastin of bovine origin in the presence of calcium chloride. It is supplied as a sterile powder that has been freeze-dried in the final container.

What is recombinant thrombin?

RECOTHROM, Thrombin topical (Recombinant), is a specific human serine protease that promotes hemostasis and acts locally when applied topically to a site of bleeding. RECOTHROM activates platelets and catalyzes the conversion of fibrinogen to fibrin, which are steps that are essential for blood clot formation.

What’s the meaning of thrombin?

Definition of thrombin : a proteolytic enzyme that is formed from prothrombin and facilitates the clotting of blood by catalyzing conversion of fibrinogen to fibrin.

What causes thrombin?

Recognized causes of a prolonged thrombin clotting time (TCT) include a decreased plasma fibrinogen level, dysfibrinogenemia, paraproteinemia, heparin contamination, elevated levels of fibrin degradation products, and liver failure.

What is thrombin time test?

The thrombin time (TT), also known as the thrombin clotting time (TCT), is a blood test that measures the time it takes for a fibrin clot to form in the plasma of a blood sample. This assesses the activity of fibrinogen and is used to investigate excessive bleeding or inappropriate blood clot formation.

What is thrombin injection?

Thrombin is an agent that causes clotting. It may be injected under ultrasound guidance into the pseudoaneurysm to clot the blood inside it. The clot is gradually reabsorbed. The procedure is performed under local anaesthetic.

How much does thrombin cost?

The average wholesale prices (US $, 2008) for 5000-IU vials of bovine thrombin and human recombinant thrombin were $87.85 and $103.20, respectively; the average wholesale price for a 4000- to 6000-IU vial of human plasma-derived thrombin was $96.00.

What is thrombin made of?

Thrombin is composed of two polypeptide chains of 36 (A chain) and 259 (B chain) residues that are covalently linked through a disulfide bond between residues C1 and C122 (Figure 4) (Bode et al. 1992; Bode 2006).

What is thrombin made from?