What protein does APC gene make?
What protein does APC gene make?
Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2. 5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion.
What do the protein products of APC do?
The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. It helps control how often a cell divides, how it attaches to other cells within a tissue, and whether a cell moves within or away from a tissue.
What protein does APC encode?
The APC gene encodes a 312-kDa protein (Fig. 2) that performs diverse cellular functions and localizes to multiple subcellular compartments. Mutations in APC are often frameshifts, insertions or deletions that introduce premature stop codons and lead to the production of a truncated APC protein.
What is the most common APC?
Exon 15 comprises >75% of the coding sequence of APC and is the most common target for both germline and somatic mutations (40).
What Signalling pathway is APC involved?
Wnt/β-catenin signaling pathway
Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/β-catenin signaling pathway.
What is APC gene mutation?
In 1997, a Johns Hopkins research team found an inherited genetic mutation called APC I1307K. Adenomatous polyposis coli (APC) is a gene that suppresses tumor growth. If the APC gene is defective, it makes the gene unstable and more susceptible to additional changes that may lead to colon and rectal cancers.
What are APC cells?
(AN-tih-jen-preh-ZEN-ting sel) A type of immune cell that boosts immune responses by showing antigens on its surface to other cells of the immune system. An antigen-presenting cell is a type of phagocyte. Also called APC.
What does APC do in the Wnt pathway?
In the context of Wnt signaling, it is well established that APC acts as a scaffold in the β-catenin destruction complex. Given that other proteins involved in this complex could be altered to activate Wnt signaling, it is curious that APC mutations predominate in CRCs.
Is APC a recessive gene?
APC-associated polyposis conditions are inherited in an autosomal dominant manner. Approximately 20–25% have the altered gene as the result of a de novo gene mutation.
What are the three types of APCs?
The main types of professional APCs are dendritic cells (DC), macrophages, and B cells.
What are examples of antigen-presenting cells?
The main types of professional antigen-presenting cells are dendritic cells, macrophages and B cells.
How does APC regulate beta catenin?
The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product β-catenin. APC binds to β-catenin through a series of homologous 15 and 20 amino acid repeats.