Which antipsychotic has the greatest risk for weight gain?

Which antipsychotic has the greatest risk for weight gain?

Olanzapine and zotepine caused significantly more weight gain than most other antipsychotics. Another head-to-head meta-analysis reported that olanzapine and clozapine cause the highest amount of weight gain, while quetiapine, risperidone and sertindole caused intermediate amounts.

What antipsychotic drugs do not cause weight gain?

Antipsychotics with a lower risk of weight gain are:

  • Aripiprazole (Abilify)
  • Asenapine (Saphris)
  • Brexipiprazole (Rexulti)
  • Haloperidol (Haldol)
  • Lurasidone (Latuda)
  • Ziprasidone (Geodon)

Do all antipsychotic drugs cause weight gain?

The extra energy or calories are stored as body fat. Many factors can affect this energy balance and lead to weight gain. The main way that antipsychotics cause weight gain is by stimulating appetite so that people feel hungry, eat more food and take in more calories….Antipsychotic medication and weight gain.

Antipsychotic Risk of weight gain
Haloperidol Low

How do you counteract antipsychotic weight gain?

“Lifestyle intervention and metformin alone and in combination demonstrated efficacy for antipsychotic-induced weight gain,” Wu and colleagues conclude. “Lifestyle intervention plus metformin showed the best effect on weight loss. Metformin alone was more effective than lifestyle intervention alone.”

Which antipsychotic medications has the greatest risk for weight gain and lipid changes?

Clozapine and olanzapine treatment are associated with the greatest risk of clinically significant weight gain, with other agents producing relatively lower levels of risk.

Why do atypical antipsychotics cause weight gain?

The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C link.

How can I prevent weight gain on olanzapine?


  1. Both metformin and berberine treatment significantly prevented olanzapine-induced weight gain and adiposity.
  2. Both metformin and berberine treatment did not affect food intake but significantly prevented olanzapine-induced brown fat loss.
  3. Drug treatments did not significantly change blood glucose or lipid levels.

What is the best antipsychotic for weight loss?

The strongest evidence for weight loss upon antipsychotic switching was for aripiprazole and ziprasidone.

How do I avoid gaining weight on Abilify?

You can help prevent weight gain from Abilify by making healthy lifestyle choices, such as exercising regularly and eating a healthy diet. Your healthcare provider can also help you manage weight gain if it happens. Abilify can also cause side effects like nausea, movement problems, or trouble sleeping.

Is antipsychotic weight gain reversible?

Conclusion. We found a significant but small reduction in weight, suggesting that antipsychotic-induced weight gain can be reversed to some degree.

How do you fight weight gain from medication?

Here are some ways to lose weight gained due to medication use:

  1. Switch to a different medication. The first strategy to consider involves changing medications.
  2. Lower medication dosage.
  3. Limit portion sizes.
  4. Exercise.
  5. Eat more protein.
  6. Talk to a dietitian.
  7. Avoid alcohol.
  8. Get enough sleep.

Which causes more weight gain olanzapine or clozapine?

Among the atypical drugs, olanzapine was associated with more weight gain than either clozapine or risperidone. The patient’s admission BMI was not associated with the amount of weight gained during subsequent antipsychotic treatment.

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