Which of the following cells produces the M-CSF and rankl?

Which of the following cells produces the M-CSF and rankl?

Macrophage colony stimulating factor (M-CSF)and receptor activator of the NF-kappaB ligand (RANKL) are produced by stromal cells and are essential for osteoclast formation.

Is M-CSF a cytokine?

Structure. M-CSF is a cytokine, being a smaller protein involved in cell signaling. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors.

What makes GM-CSF?

GM-CSF is produced by various cell types including macrophages, mast cells, T cells, fibroblasts and endothelial cells 8, 9, mostly in response to immune activation and cytokines that mediate inflammation.

What cell produces RANKL?

RANKL exists as a homotrimeric protein and is typically membrane-bound on osteoblastic and activated T cells or is secreted by some cells, such as activated T cells (43–45).

Is RANKL secreted by osteoblasts?

RANKL is a member of the tumor necrosis factor (TNF) super-family and is produced on osteoblasts and T cells.

Where is M-CSF from?

Most CSF is formed in the cerebral ventricles. Possible sites of origin include the choroid plexus, the ependyma, and the parenchyma[2]. Anatomically, choroid plexus tissue is floating in the cerebrospinal fluid of the lateral, third, and fourth ventricles.

What is the function of M-CSF?

Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that regulates the proliferation, differentiation, and functional activation of monocytes. Normally detected in human serum, M-CSF plays an important role in enhancing the effector functions of mature monocytes and macrophages.

What cell releases CSF GM?

GM-CSF is produced by multiple cell types such as activated T cells, B cells, macrophages, monocytes, mast cells, vascular endothelial cells, and fibroblasts (2).

What would trigger the release of colony stimulating factors CSFs )?

When do immune cells release colony stimulating factor? They release it in response to a bacterial infection.

What is meant by Hemopoietic?

(hee-MA-toh-poy-EH-tik stem sel) An immature cell that can develop into all types of blood cells, including white blood cells, red blood cells, and platelets. Hematopoietic stem cells are found in the peripheral blood and the bone marrow. Also called blood stem cell.

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