Why do Dihydropyridines cause edema?

Why do Dihydropyridines cause edema?

Dihydropyridine CCBs cause selective vasodilation of the arteriolar side of the circulation. Administration of CCBs as monotherapy causes increased pressure within the capillary bed, leading to fluid transudation and oedema formation.

Are CCBs contraindicated in pregnancy?

Calcium channel blockers can be safely used during pregnancy and breastfeeding.

What are the adverse effects of dihydropyridine type calcium channel blockers?

Common side effects of dihydropyridine calcium channel blockers may include:

  • Headache.
  • Flushing (involuntary, temporary reddening of the skin, usually seen in the face)
  • Dizziness.
  • Lightheadedness.
  • Blood pressure fluctuation.
  • Swelling of foot, ankles, and hands.
  • Heart burn.
  • Constipation.

Why do DHP CCBs cause peripheral edema?

Objective: Peripheral edema is considered to be a common and annoying adverse effect of calcium channel blockers (CCBs). It has been thought to occur secondary to arteriolar dilatation causing intracapillary hypertension and fluid extravasation.

Which calcium channel blocker causes the most edema?

Pedal edema is one of the most common adverse effects of calcium antagonists. It has been observed with all available dihydropyridine agents, but it also seems to occur to a lesser extent with verapamil and diltiazem.

Is amlodipine a dihydropyridine calcium channel blocker?

Amlodipine is an oral dihydropyridine calcium channel blocker. Amlodipine is available as amlodipine besylate, initially approved in 1987 by the Food and Drug Administration (FDA).

Why is amlodipine not given in pregnancy?

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Why is amlodipine not used in pregnancy?

Amlodipine and Pregnancy Amlodipine falls into category C. There are no good studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if amlodipine will harm your unborn baby.

What is the difference between dihydropyridine and non dihydropyridine calcium channel blockers?

The dihydropyridines are more vascular selective and the non-dihydropyridines are more myocardial selective and tend to reduce the heart rate. Further important differences are between short- and long-acting forms of the calcium channel antagonists.

What is the difference between dihydropyridine and Nondihydropyridine?

Dihydropyridine CCBs have predominantly peripheral vasodilatory actions, whereas nondihydropyridine CCBs have significant sinoatrial (SA) and AV node depressant effects and possible myocardial depressant effects with lesser amounts of peripheral vasodilation.

How does amlodipine cause edema?

Cause. Edema commonly occurs with calcium channel blockers because the drugs trigger the dilation of blood vessels. The dilation, in turn, lowers the blood pressure and improves the flow of blood throughout the body.

Which calcium channel blockers do not cause edema?

Edema will diminish upon conversion from a dihydropyridine CCB to a nondihydropyridine CCB such as verapamil or diltiazem. In addition, the newer, third-generation dihydropyridine CCBs such as lacidipine,[32,33] manidipine, and lercanidipine[32,33,34,35] are regularly reported to cause less peripheral edema.