Why does hemolysis affect potassium?

Why does hemolysis affect potassium?

Of all routine blood tests plasma/serum potassium measurement is one of the most sensitive to the effect of hemolysis because red-cell potassium concentration is so much higher than that of plasma (approximately 20 times higher); hemolysis causes a spuriously high plasma potassium concentration.

How much does hemolysis raise potassium?

relation between potassium and haemolysis increase, as indicated in Figure1. The potassium increase ranged from 0.0029 — 0.0053mmol/L per unit of HI, with a mean of 0.0036 mmol/L. Thus, 1g/L of free haemoglo- bin or 100 units of HI will cause a 0.36mmol/L (rounded off to 0.4 mmol/L) increase in potassium.

What contributes to hemolysis and elevated potassium levels?

Pseudohyperkalemia from in vitro hemolysis is the most common cause of falsely elevated potassium, and it is most often caused by pressure gradients created during draws, often with a syringe or from an indwelling catheter.

What is elevated in a hemolyzed blood sample?

Hemolysis may falsely increase the following analytes: AST, alanine transaminase (ALT), LDH, total bilirubin, glucose, calcium, phosphorus, total protein, albumin, magnesium, amylase, lipase, creatine kinase (CK), iron, hemoglobin, and mean corpuscular hemoglobin concentration (MCHC).

What lab tests does hemolysis affect?

Certain lab tests can be affected and the reported results will be inaccurate. It falsely decreases values such as RBC’s, HCT, and aPTT. It can also falsely elevate potassium, ammonia, magnesium, phosphorus, AST, ALT, LDH and PT.

What does it mean when a blood test is hemolyzed?

The term hemolysis designates the pathological process of breakdown of red blood cells in blood, which is typically accompanied by varying degrees of red tinge in serum or plasma once the whole blood specimen has been centrifuged.

How does hemolysis affect blood results?

It falsely decreases values such as RBC’s, HCT, and aPTT. It can also falsely elevate potassium, ammonia, magnesium, phosphorus, AST, ALT, LDH and PT.

Can internal bleeding cause high potassium?

If you are bleeding internally, you may have hyperkalemia. Some medications that contain potassium, or medications that preserve the amount of potassium that is excreted through your kidneys, can cause hyperkalemia.

What labs are affected by hemolysis?

What happens when blood hemolyzed?

“Hemo” means blood, of course; “lysis” means to rupture or the destruction of cells. So hemolysis is literally the destruction of blood cells, specifically red blood cells. When red cells rupture, they spill their contents, mostly hemoglobin, into their surroundings.

How does hemolysis affect electrolytes?

Moderate hemolysis significantly increased plasma phosphorus levels. Marked hemolysis significantly increased plasma values of potassium, phosphorus, total protein, and aspartate aminotransferase.