What is ddMVAC chemotherapy?

What is ddMVAC chemotherapy?

A dose-dense combination of methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) followed by cystectomy may be a more effective treatment option than standard neoadjuvant chemotherapy (NAC) among patients with bladder cancer, according to a study published in JAMA Oncology. 1.

How is MVAC administered?

Administer IV push over one minute. Dilute in 50 mL NS* and administer over three to five minutes or IV push through a peripheral line. Dilute with 250 mL NS* and administer over 60 minutes. Do not administer with aluminum needles or sets.

What is vinblastine made of?

Vinblastine is a chemical analogue of vincristine, an alkaloid derived from the Madagascar periwinkle plant Vinca rosea (Catharanthus roseus), from which it derives its name.

How many cycles of gemcitabine and cisplatin can you have?

You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months.

What is Folfirinox regimen?

An abbreviation for a chemotherapy combination used to treat pancreatic cancer that has spread to other parts of the body. It includes the drugs leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin. Also called FOLFIRINOX.

Are vincristine and vinblastine the same?

The difference between vinblastine (1) and vincristine (2) is that the former has a methyl while the latter has a formyl group on the indole nitrogen of the vindoline skeleton (Figure 1).

Why is vinblastine used for chemotherapy?

Vinblastine works by stopping the cancer cells from separating into 2 new cells. So it blocks the growth of the cancer.

What’s the difference between adjuvant and neoadjuvant?

Neoadjuvant chemotherapy is delivered before surgery with the goal of shrinking a tumor or stopping the spread of cancer to make surgery less invasive and more effective. Adjuvant chemotherapy is administered after surgery to kill any remaining cancer cells with the goal of reducing the chances of recurrence.

How effective is gemcitabine?

Since 1997, gemcitabine therapy has been the standard first-line treatment for patients with unresectable locally advanced or metastatic pancreatic cancer. Among patients with metastatic disease, the 5-year survival rate is only 2%,1 and 1-year survival rates of 17 to 23% have been reported with gemcitabine.

How long can you take gemcitabine?

You usually have gemcitabine as a course of several cycles of treatment. This means that you have the drug and then a rest to allow your body to recover. Usually a cycle of gemcitabine is over 3 to 4 weeks (21 to 28 days). You usually have gemcitabine once a week for 2 or 3 weeks and then a week with no treatment.